Endocrine Abstracts

Introduction: Sensitivity and specificity of thyroid cytology in our series of thyroidectomies were evaluated.Material and methods: A retrospective, multicentre study of 1567 thyroidectomies performed in the eight hospitals of Castilla La Mancha (Spain) during the years 2010–2013.Results: The cytological results were benign in 37.6% of cases, malignant or suspicious of malignancy in 17.3% (10 and 7.3% respectively). In 4.1% of...

Visceral adipose tissue (VAT) dysfunction is closely associated with the rising incidence of cardiovascular diseases (CVD) and type 2 diabetes mellitus. Two distinct types of adipose tissue, white (WAT) and brown (BAT), are present in mammals. Development of ‘brown-like’ adipocytes within white adipose tissue has potential antiobesity and insulin-sensitizing effects. Genetic manipulation of cGMP formation suggests a new role for this pathway in preadipocytes commitme...

Introduction: Polycystic ovary syndrome (PCOS) affects 5–8% of reproductive-age women. The morbidity related to PCOS may include insulin-resistance, type 2 diabetes mellitus (T2DM), obesity, hypertension, cardiovascular disease and infertility. We aimed to evaluate the clinico-biochemical characteristics of PCOS women and establish its relationship with fertility treatment outcomes.Methods: We reviewed clinical records of PCOS women (Rotterdam crite...

Introduction: In subjects with erectile dysfunction (ED) responding poorly to sildenafil, metformin was reported to improve erections.Aims: To investigate metformin’s mechanism of action on erectile function, particularly focusing on adenosine (ADO), and NO signalling in an animal model of high fat diet (HFD)-induced metabolic syndrome (MetS).Methods: In vitro contractility studies of penile strips. Penile expression ...

The aryl hydrocarbon receptor interacting protein gene has been mainly involved in the pathogenesis of GH/PRL-secreting pituitary adenomas (PA). We wished to study the significance of AIP expression in clinically non-functioning PA (NFPA).Material and methods: 48 NFPA -27 gonadotroph (GnPA), 21 null cell (ncPA) – were studied for AIP, βFSH and cyclin D1 expression by real-time RT-PCR (qRT), compared with four normal post-mortem pituitaries (NP)...

Introduction: Utilization rates of fertility preservation among transgender adolescents (TA) are low. Few studies have addressed the reproductive desires of this population. The aim of this study was to assess TA parenthood goals, attitudes about fertility preservation (FP) and perceived barriers to successful gamete banking.Methods: Transgender adolescents who attended the Gender Identity Development Service (GIDS - endocrine clinic) between March and J...

Background: Male adolescents with hypogonadotropic hypogonadism (HH) or delayed puberty start pubertal induction from 12–14 years. Testosterone obtains secondarysexual characteristics and improves psychosocial well being. Gonadotropin releasing hormone (GnRH) or recombinant FSH (rFSH) and human chorionic gonadotropin (hCG) generate testicular growth (fertility) and testicular testosterone production. HCG-rFSH treatment increase testis size and improves the quality of life...

Background: Fertility preservation (FP) amongst transgender adolescents (TA) is receiving more attention as individuals are transitioning at younger ages. Parents have a key role at exploring options for their children and are usually the ones responsible for consenting to interventions. Our aim was to explore parent’s attitudes regarding their offspring parenthood goals, FP counselling and perceived barriers to successful gamete banking.Methods: Pa...

Background: The prevalence of adrenal incidentalomas has increased. The malignancy is determined by radiographic appearance and, secondly, by the size. Adenomas manifest a low attenuation on computed tomography (CT) (<10 Hounsfield Units(HU)).The cut-off point of 10 HU has been proposed to discriminate benign and malignant lesions.Objective: To determine if the cut-off point of 10 HU is useful in clinical practice to discriminate benign and malignant...

Introduction: An aim of the ERNs is empowering patients, by education & learning about their experiences after diagnosis of a rare endocrine disease (RED), to identify gaps and improve outcome. Thus, EndoERN Work Package 4 designed a survey, to learn about patients perceptions on quality of care and existing gaps in diagnosis/management.Aim: Evaluate results of a 21 question survey answered on-line on a Likert scale by individual patients with RED or...